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بیوپسی مایع
However, the advantage of applying multiple DNA, RNA, and protein- based assays to study whole tumor cells in the circulation (so-called liquid biopsies) is currently restricted by the need for complex cellular isolation platforms.
Simple, multiplexed, PCR-based barcoding of DNA enables sensitive mutation detection in liquid biopsies using sequencing.
The possibility of probing the molecular landscape of solid tumours via a blood draw, with major implications for research and patient care, has attracted remarkable interest among the oncology com munity; the term 'liquid biopsy' is often used to describe this approach6.
Many studies have illustrated the potential of liquid biopsy approaches to determine the genomic profile of patients with cancer, monitor treatment responses and quantify minimal residual disease, and assess the emer gence of therapy resistance.
In addition to blood, several other body fluids such as urine7, saliva8, pleural effusions9, and cerebrospinal fluid (CSF)10, as well as stool11, have been shown to contain tumourderived genetic material, and our ability to exploit liquid biopsies for diagnostic purposes will further expand in the future.
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